Lan Kluwe Selected Research

Neurofibrosarcoma (MPNST)

7/2020	Upregulated immuno-modulator PD-L1 in malignant peripheral nerve sheath tumors provides a potential biomarker and a therapeutic target.
1/2014	Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro.
4/2013	Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors.
1/2013	Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.
1/2013	Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition.
10/2010	Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.
10/2009	Genome-wide high-resolution analysis of DNA copy number alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array.
7/2009	Ral overactivation in malignant peripheral nerve sheath tumors.
8/2008	Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1.
3/2008	Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals.

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Lan Kluwe Research Topics

Disease

30	Neoplasms (Cancer) 03/2021 - 05/2004
14	Neurofibrosarcoma (MPNST) 07/2020 - 05/2004
10	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2019 - 05/2004
10	Neurofibroma 01/2019 - 08/2004
9	Plexiform Neurofibroma 07/2021 - 08/2004
6	Hemorrhage 07/2016 - 07/2014
4	Carcinoma (Carcinomatosis) 12/2020 - 12/2013
3	Neurofibromatosis 2 (Neurofibromatosis Type II) 11/2019 - 01/2002
3	Squamous Cell Carcinoma of Head and Neck 01/2017 - 03/2014
2	Acoustic Neuroma (Acoustic Neurinoma) 10/2020 - 11/2019
2	Body Weight (Weight, Body) 01/2015 - 01/2014
1	Ovarian Neoplasms (Ovarian Cancer) 12/2021
1	Urinary Bladder Neoplasms (Bladder Cancer) 12/2020
1	Lymphatic Metastasis 12/2020
1	Residual Neoplasm 10/2020
1	Wounds and Injuries (Trauma) 09/2020
1	Lipoma (Lipomata) 01/2020
1	Dry Eye Syndromes (Dry Eye Syndrome) 01/2020
1	Melanoma (Melanoma, Malignant) 04/2019
1	Mouth Neoplasms (Oral Cancer) 01/2017
1	Edentulous Jaw 08/2016
1	Neurilemmoma (Schwannoma) 01/2016
1	Communicable Diseases (Infectious Diseases) 04/2015
1	Diarrhea 01/2015
1	Constipation 01/2015
1	Vomiting 01/2015
1	Nausea 01/2015
1	Tinnitus 01/2015
1	Thromboembolism 01/2015
1	Dizziness (Lightheadedness) 01/2015
1	Leukemia 01/2014
1	Papillomavirus Infections 10/2013
1	Ependymoma 12/2012

Drug/Important Bio-Agent (IBA)

9	Biomarkers (Surrogate Marker)IBA 07/2020 - 03/2006
8	DNA (Deoxyribonucleic Acid)IBA 12/2020 - 01/2002
5	Pharmaceutical PreparationsIBA 04/2019 - 01/2014
5	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 07/2016 - 07/2014
4	nilotinib FDA Link 07/2021 - 01/2014
4	Imatinib Mesylate (Gleevec)FDA Link 07/2021 - 05/2010
3	AnticoagulantsIBA 07/2016 - 07/2014
2	Bevacizumab (Avastin)FDA Link 10/2020 - 11/2019
2	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 05/2004
2	ErbB Receptors (EGF Receptor)IBA 01/2017 - 03/2006
2	Clopidogrel (Plavix)FDA Link 01/2015 - 01/2015
2	Proteins (Proteins, Gene)FDA Link 10/2010 - 03/2006
1	Circulating Tumor DNAIBA 12/2021
1	calcipotriene (calcipotriol)FDA LinkGeneric 07/2021
1	Cell-Free Nucleic AcidsIBA 12/2020
1	Serum AlbuminIBA 09/2020
1	Adhesives (Glues)IBA 09/2020
1	Biocompatible Materials (Biomaterials)IBA 09/2020
1	CollagenIBA 09/2020
1	VemurafenibIBA 04/2019
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	Vitamin D FDA LinkGeneric 01/2019
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2019
1	hydroxide ionIBA 01/2019
1	Dental Implants (Dental Implant)IBA 08/2016
1	RivaroxabanIBA 07/2016
1	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 07/2016
1	DNA Transposable Elements (Element, IS)IBA 03/2016
1	Therapeutic UsesIBA 03/2016
1	Anti-Bacterial Agents (Antibiotics)IBA 04/2015
1	AntibodiesIBA 04/2015
1	tiboloneIBA 01/2015
1	Phenprocoumon (Liquamar)FDA Link 07/2014
1	Cholecalciferol (Vitamin D3)FDA Link 05/2014
1	Calcifediol (Calcidiol)FDA Link 05/2014
1	Growth Factor ReceptorsIBA 03/2014
1	Tyrosine Kinase InhibitorsIBA 01/2014
1	Phosphotransferases (Kinase)IBA 01/2014
1	CytokinesIBA 04/2013
1	Chemokine CCL5IBA 04/2013
1	Insulin-Like Growth Factor Binding Protein 1IBA 04/2013
1	Neurofibromin 1 (Neurofibromin)IBA 01/2013
1	MLN 8237IBA 01/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013
1	LigandsIBA 01/2013
1	PhytochemicalsIBA 01/2013
1	CurcuminIBA 01/2013
1	Aurora KinasesIBA 01/2013
1	Aurora Kinase AIBA 01/2013
1	Mucin-1 (CA 15-3 Antigen)IBA 12/2012

Therapy/Procedure

10	Therapeutics 12/2021 - 06/2004
4	Ligation 12/2020 - 03/2009
4	Oral Surgery (Maxillofacial Surgery) 09/2020 - 01/2015
2	Lasers (Laser) 03/2021 - 09/2020
2	Decompression 10/2020 - 08/2019
2	Adjuvant Chemotherapy 03/2016 - 03/2016
2	Operative Surgical Procedures 01/2015 - 07/2014
2	Osteotomy 01/2015 - 01/2015
2	Dermatologic Surgical Procedures 07/2014 - 07/2014
2	Drug Therapy (Chemotherapy) 01/2013 - 03/2006
1	Cystectomy 12/2020
1	Oral Surgical Procedures 07/2016
1	Sutures (Suture) 07/2016
1	Nerve Crush 01/2016
1	Free Tissue Flaps 04/2015
1	Neoadjuvant Therapy 01/2014